Longitudinal MRI-visible perivascular space (PVS) changes with long-duration spaceflight.

ABSTRACT: Humans are exposed to extreme environmental stressors during spaceflight and return with alterations in brain structure and shifts in intracranial fluids. To date, no studies have evaluated the effects of spaceflight on perivascular spaces (PVSs) within the brain, which are believed to facilitate fluid drainage and brain homeostasis. Here, we examined how the number and morphology of magnetic resonance imaging (MRI)-visible PVSs are affected by spaceflight, including prior spaceflight experience. Fifteen astronauts underwent six T₁-weighted 3 T MRI scans, twice prior to launch and four times following their return to Earth after ~ 6-month missions to the International Space Station. White matter MRI-visible PVS number and morphology were calculated using an established, automate

SUBMITTER: Hupfeld KE 

PROVIDER: S-EPMC9072425 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature