Clinical Relevance of the Tumor Location-Modified Lauren Classification System for Gastric Cancer in a Western Population.

ABSTRACT:

Background

The Tumor Location-Modified Laurén Classification (MLC) system combines Laurén histologic subtype and anatomic tumor location. It divides gastric tumors into proximal non-diffuse (PND), distal non-diffuse (DND), and diffuse (D) types. The optimum classification of patients with Laurén mixed tumors in this system is not clear due to its grouping with both diffuse and non-diffuse types in previous studies. The clinical relevance of the MLC in a Western population has not been examined.

Methods

A cohort study investigated 404 patients who underwent gastrectomy for gastric adenocarcinoma between 2005 and 2020. The classification of Laurén mixed tumors was evaluated using receiver operating characteristic (ROC) curve analysis and comparison of clinicopathologic charact

SUBMITTER: Moore JL 

PROVIDER: S-EPMC9072452 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature