Genetics of Type 2 Diabetes: Implications from Large-Scale Studies.

ABSTRACT:

Purpose of review

Type 2 diabetes (T2D) is a multifactorial, heritable syndrome characterized by dysregulated glucose homeostasis that results from impaired insulin secretion and insulin resistance. Genetic association studies have successfully identified hundreds of T2D risk loci implicating many genes in disease pathogenesis. In this review, we provide an overview of the recent T2D genetic studies from the past 3 years with particular focus on the effects of sample size and ancestral diversity on genetic discovery as well as discuss recent work on the use and limitations of genetic risk scores (GRS) for T2D risk prediction.

Recent findings

Recent large-scale, multi-ancestry genetic studies of T2D have identified over 500 novel risk loci. The genetic variants (i.e., single

SUBMITTER: DeForest N 

PROVIDER: S-EPMC9072491 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature