Oscillations in K(ATP) conductance drive slow calcium oscillations in pancreatic β-cells.

ABSTRACT: ATP-sensitive K⁺ (K(ATP)) channels were first reported in the β-cells of pancreatic islets in 1984, and it was soon established that they are the primary means by which the blood glucose level is transduced to cellular electrical activity and consequently insulin secretion. However, the role that the K(ATP) channels play in driving the bursting electrical activity of islet β-cells, which drives pulsatile insulin secretion, remains unclear. One difficulty is that bursting is abolished when several different ion channel types are blocked pharmacologically or genetically, making it challenging to distinguish causation from correlation. Here, we demonstrate a means for determining whether activity-dependent oscillations in K(ATP) conductance play the primary role in driving electric

SUBMITTER: Marinelli I 

PROVIDER: S-EPMC9072586 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature