Inhibitor-conjugated harmonic nanoparticles targeting fibroblast activation protein.

ABSTRACT: The recent progress in the engineering of nanosized inorganic materials presenting tailored physical properties and reactive surface for post-functionalization has opened promising avenues for the use of nanoparticles (NPs) in diagnosis and therapeutic intervention. Surface decoration of metal oxide NPs with ligands modulating circulation time, cellular uptake, affinity and extravasation through active targeting led to efficient cancer specific bioimaging probes. The most relevant cancer biomarkers studied so far include surface and transmembrane cancer cell receptors. More recently, tumor microenvironments and more specifically the fibroblastic element of the tumor stroma have emerged as a valuable target for diagnosis and treatment of several types of cancers. In this study, a low molecu

SUBMITTER: De Matos R 

PROVIDER: S-EPMC9072645 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature