Enantioselective bromination of axially chiral cyanoarenes in the presence of bifunctional organocatalysts.

ABSTRACT: Enantioselective bromination of axially chiral cyanoarenes bearing high intrinsic rotational barriers via dynamic kinetic resolution using bifunctional organocatalysts is reported. Sequential addition of a brominating reagent in several portions at an optimized temperature was effective in accomplishing high enantioselectivities.

SUBMITTER: Wada Y 

PROVIDER: S-EPMC9072646 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature