Systemic immune-inflammation index is associated with white matter hyperintensity volume.

ABSTRACT: Systemic immune-inflammation index (SII) is a novel inflammatory marker based on the composition ratio of blood cell counts. In this study, we evaluated the association between the SII and cerebral small vessel disease (cSVD) in health check-up participants. We evaluated participants from our health check-up registry between 2006 and 2013. The SII was calculated using the following formula: SII = (platelet count × neutrophil count)/lymphocyte count. cSVD was assessed by considering white matter hyperintensity (WMH) volume, lacunes, and cerebral microbleeds (CMBs). A total of 3187 participants were assessed. In multivariable linear regression analysis, the SII was significantly related to WMH volume [β = 0.120, 95% confidence interval (CI) 0.050-0.189]. However, lacunes and CMBs showed no s

SUBMITTER: Nam KW 

PROVIDER: S-EPMC9072679 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature