Customizing the extracellular vesicles release and effect by strategizing surface functionalization of titanium.

ABSTRACT: Metallic material functionalization with Extracellular Vesicles (EVs) is a desirable therapeutic approach to improve regenerative procedures. Among the different functionalization strategies available, here we have compared drop casting on machined Ti surfaces, drop casting on nanostructured TiO₂ surfaces and polymeric entrapment with polydopamine. EVs are a heterogeneous population of communication nanovesicles released by cells that are being intensively investigated for their use in therapeutics. We have selected platelet derived EVs for Ti surface coating due to their demonstrated osteoinductive properties. Our results show that each functionalization strategy leads to differences in the size of EV populations attached to and released from the metallic implants, which, in tu

SUBMITTER: Antich-Rossello M 

PROVIDER: S-EPMC9072683 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature