Extracellular Vesicles and the Inflammasome: An Intricate Network Sustaining Chemoresistance.

ABSTRACT: Extracellular vesicles (EVs) are membrane enclosed spherical particles devoted to intercellular communication. Cancer-derived EVs (Ca-EVs) are deeply involved in tumor microenvironment remodeling, modifying the inflammatory phenotype of cancerous and non-cancerous residing cells. Inflammation plays a pivotal role in initiation, development, and progression of many types of malignancies. The key feature of cancer-related inflammation is the production of cytokines that incessantly modify of the surrounding environment. Interleukin-1β (IL-1β) is one of the most powerful cytokines, influencing all the initiation-to-progression stages of many types of cancers and represents an emerging critical contributor to chemoresistance. IL-1β production strictly depends on the activation of inflammasome,

SUBMITTER: Mezzasoma L 

PROVIDER: S-EPMC9072732 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature