Seven membered chelate Pt(ii) complexes with 2,3-di(2-pyridyl)quinoxaline ligands: studies of substitution kinetics by sulfur donor nucleophiles, interactions with CT-DNA, BSA and in vitro cytotoxicity activities.

ABSTRACT: Dichloro platinum(ii) complexes coordinated with 2,3-di(2-pyridyl)quinoxaline ligands which form seven-membered chelates namely, bpqPtCl₂, dmbpqPtCl₂ and bbqPtCl₂ (where bpq, dmbpq and bbq are 2,3-di(2-pyridyl)quinoxaline, 6,7-dimethyl-2,3-di(2-pyridyl)quinoxaline and 2,3-bis(2'pyriyl)benzo[g]quinoxaline, respectively) were synthesized, characterised and their respective hydrated product complexes namely, bpqPt(OH₂)₂ ²⁺, dmbpqPt(OH₂)₂ ²⁺ and bbqPt(OH₂)₂ ²⁺ were prepared by chloride metathesis. The substitution kinetics of the aquated cations by thiourea nucleophiles indicated that the two aqua ligands are substituted simultaneously according to the rate

SUBMITTER: Bellam R 

PROVIDER: S-EPMC9072748 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature