Anti-hypotensive effect of "Yahom Navakot" in rats with orthostatic hypotension.

ABSTRACT:

Background and aim

Yahom Navakot (YN), is a Thai traditional medicine, consisting of 54 plants, for treating fainting and dizziness. Thus, YN might relieve orthostatic hypotension (OH) symptoms, but its therapeutic action is unclear. Therefore, this study evaluated YN in OH rats, using a head-up tilt test (HUT).

Experimental procedure

Rats were anesthetized, and OH induced via a 90^oHUT, before and after administering vehicle, a YN powder suspension (10, 100 mg/kg), a YN aqueous extract (100 mg/kg), and midodrine (5 mg/kg). The systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), pulse pressure (PP) and heart rate (HR) were determined via the carotid artery. Plasma noradrenaline (NA) was evaluated. YN-induced vasoconstr

SUBMITTER: Inchan A 

PROVIDER: S-EPMC9072801 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature