Palladium-catalyzed oxidative cross-coupling for the synthesis of α-amino ketones.

ABSTRACT: A novel oxidative cross-coupling reaction for the synthesis of α-aryl α-amino ketones in the presence of palladium catalysts using T⁺BF₄ ^- as an oxidant has been developed. This transformation was achieved by direct C-H oxidation of α-aminocarbonyl compounds and arylation. The mild reaction has a broad reaction scope and gives desired α-aryl α-amino ketones in moderate to excellent yields.

SUBMITTER: Wei XH 

PROVIDER: S-EPMC9072988 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature