Association of single nucleotide polymorphism variations in CRYAA and CRYAB genes with congenital cataract in Pakistani population.

ABSTRACT:

Background

The purpose of present study was to analyze the association of single nucleotide polymorphism (SNPs) variant in CRYAA and CRYAB genes with Congenital Cataract.

Method

Total 196 blood samples of children were collected, out of which 102 samples were congenital cataract (case group) and 94 samples were normal individuals (control group). Genomic DNA was extracted by using optimized inorganic method. Tetra primers for SNPs were designed and TETRA-ARMs assay was performed on both groups. Genotypic, allelic frequency and haplotype analyses were obtained by using SNPstats software.

Results

The coordination of genotypic and allelic frequencies of CRYAA and CRYAB genes variants and the association between case and control groups showed i

SUBMITTER: Jarwar P 

PROVIDER: S-EPMC9073017 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature