Independent case-control study in KCNJ11 gene polymorphism with Type 2 diabetes Mellitus.

ABSTRACT:

Background

Type 2 Diabetes Mellitus (T2DM) is the most common form of diabetes in the aging population. This chronic metabolic disorder has discovered many candidate genes, and KCNJ11 was one of the genes associated with insulin secretion pathways mediated by potassium channels. There have been limited studies on the rs5210 polymorphism in T2DM patients, and none of them have been conducted in Saudi Arabia.

Aim

The aim of this study is to investigate at genotyping levels of rs5210 polymorphism in the KCNJ11 gene in older population with T2DM in the Saudi Population.

Methods

Based on the sample size design, this case-control study included 102 T2DM cases and 102 controls. Using the PCR-RFLP assay, 204 patients extracted DNA was genotyped for the rs5210 po

SUBMITTER: Alqadri N 

PROVIDER: S-EPMC9073069 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature