Heterocyclic iodoniums as versatile synthons to approach diversified polycyclic heteroarenes.

ABSTRACT: Polycyclic heteroarenes are important scaffolds in the construction of pharmaceuticals. We have previously developed a series of novel heterocyclic iodoniums. In our current work, these unique iodoniums were employed to construct various complex polycyclic heteroarenes with structural diversity via tandem dual arylations. As a result, indole, thiophene and triphenylene motifs were fused into these heterocycles with high molecular quality, which might provide promising fragments in drug discovery. Moreover, these heterocycles could be diversified at a late stage.

SUBMITTER: Zhu D 

PROVIDER: S-EPMC9073335 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature