Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging.

ABSTRACT: A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX® nanoparticles via a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiolabelled with ⁶⁴Cu, and evaluated in a mice TSA tumor model using multimodal (PET/MRI/optical) imaging.

SUBMITTER: Thakare V 

PROVIDER: S-EPMC9073358 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature