Evaluation of determinants of the serological response to the quadrivalent split-inactivated influenza vaccine.

ABSTRACT: The seasonal influenza vaccine is only effective in half of the vaccinated population. To identify determinants of vaccine efficacy, we used data from > 1,300 vaccination events to predict the response to vaccination measured as seroconversion as well as hemagglutination inhibition (HAI) titer levels one year after. We evaluated the predictive capabilities of age, body mass index (BMI), sex, race, comorbidities, vaccination history, and baseline HAI titers, as well as vaccination month and vaccine dose in multiple linear regression models. The models predicted the categorical response for > 75% of the cases in all subsets with one exception. Prior vaccination, baseline titer level, and age were the major determinants of seroconversion, all of which had negative effects. Further, we identif

SUBMITTER: Wu S 

PROVIDER: S-EPMC9073386 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature