Metabolic disorders and the risk of head and neck cancer: a protocol for a systematic review and meta-analysis.

ABSTRACT:

Introduction

Head and neck cancer squamous cell carcinoma (HNSCC) is the sixth most common cancer internationally. Established risk factors include smoking, alcohol and presence of human papillomavirus (HPV). The incidence rate of new disease continues to rise, despite falls in alcohol consumption and a reduction in smoking, the rising rates are unlikely to be solely attributed to HPV status alone. Obesity and its associated conditions such as type 2 diabetes (T2D) are implicated in the risk and progression of a variety of cancers, but there is paucity of evidence regarding its role in HNSCC.

Methods and analysis

A systematic review of cohort studies, reporting a risk of incident HNSCC, will be included. A systematic search strategy has been developed, multiple databases wil

SUBMITTER: Gormley A 

PROVIDER: S-EPMC9073393 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature