Dataset Information

Deferred consent in emergency obstetric research: findings from qualitative interviews with women and recruiters in the ACROBAT pilot trial for severe postpartum haemorrhage.

ABSTRACT:

Objective

The ACROBAT pilot trial of early cryoprecipitate for severe postpartum haemorrhage used deferred consent procedures. Pretrial discussions with a patient and public involvement group found mixed views towards deferred consent. This study aimed to build an understanding of how the deferred consent procedures worked in practice, to inform plans for a full-scale trial.

Setting

Qualitative interview study within a cluster-randomised pilot trial, involving four London maternity services.

Participants

Individual interviews were conducted postnatally with 10 women who had received blood transfusion for severe postpartum haemorrhage and had consented to the trial. We also interviewed four 'recruiters'-two research midwives and two clinical trials practitioners who conducted trial recruitment.

Results

Consent procedures in the ACROBAT pilot trial were generally acceptable and the intervention was viewed as low risk, but most women did not remember much about the consent conversation. As per trial protocol, recruiters sought to consent women before hospital discharge, but this time pressure had to be balanced against the need to ensure women were not approached when distressed or very unwell. Extra efforts had to be made to communicate trial information to women due to the exhaustion of their recovery and competing demands for their attention. Participant information was further complicated by explanations about the cluster design and change in transfusion process, even though the consent sought was for access to medical data.

Conclusion

Our findings indicate that deferred consent procedures raise similar concerns as taking consent when emergency obstetric research is occurring-that is, the risk that participants may conflate research with clinical care, and that their ability to process trial information may be impacted by the stressful nature of recovery and newborn care. A future trial may support more meaningful informed consent by extending the window of consent discussion and ensuring trial information is minimal and easy to understand.

Trial registration number

ISRCTN12146519.

SUBMITTER: Sweeney L

PROVIDER: S-EPMC9073399 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Publications

Deferred consent in emergency obstetric research: findings from qualitative interviews with women and recruiters in the <i>ACROBAT</i> pilot trial for severe postpartum haemorrhage.

Sweeney Lorna L Lanz Doris D Daru Jahnavi J Rasijeff Annika M P AMP Khanom Farzana F Thomas Amy A Harden Angela A Green Laura L

BMJ open 20220504 5

<h4>Objective</h4>The ACROBAT pilot trial of early cryoprecipitate for severe postpartum haemorrhage used deferred consent procedures. Pretrial discussions with a patient and public involvement group found mixed views towards deferred consent. This study aimed to build an understanding of how the deferred consent procedures worked in practice, to inform plans for a full-scale trial.<h4>Setting</h4>Qualitative interview study within a cluster-randomised pilot trial, involving four London maternit ...[more]

PMID: 35508349

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