Interferon‑stimulated gene 15 promotes progression of endometrial carcinoma and weakens antitumor immune response.

ABSTRACT: Endometrial carcinoma (EC) is one of the most common gynecological cancers with a poor prognosis. Therefore, clarifying the details of the molecular mechanisms is of great importance for EC diagnosis and clinical management. Interferon‑stimulated gene 15 (ISG15) plays an important role in the development of various cancers. However, its role in EC remains unclear. High ISG15 expression was observed in EC, which was associated with poor clinical outcomes and pathological stage of patients with EC, thus representing a promising marker for EC progression. Further exploratory analysis revealed that the elevated ISG15 levels in EC were driven by aberrant DNA methylation, independent of copy number variation and specific transcription factor aberrations. Accordingly, knockdown of ISG15 by small

SUBMITTER: Zhao X 

PROVIDER: S-EPMC9073416 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature