Propagating patterns of intrinsic activity along macroscale gradients coordinate functional connections across the whole brain.

ABSTRACT: The intrinsic activity of the human brain, observed with resting-state fMRI (rsfMRI) and functional connectivity, exhibits macroscale spatial organization such as functional networks and gradients. Dynamic analysis techniques have shown that functional connectivity is a mere summary of time-varying patterns with distinct spatial and temporal characteristics. A better understanding of these patterns might provide insight into aspects of the brain's intrinsic activity that cannot be inferred by functional connectivity or the spatial maps derived from it, such as functional networks and gradients. Here, we describe three spatiotemporal patterns of coordinated activity across the whole brain obtained by averaging similar ~20-second-long segments of rsfMRI timeseries. In each of these patterns,

SUBMITTER: Yousefi B 

PROVIDER: S-EPMC9073587 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature