Mutation, selection, and the prevalence of the Caenorhabditis elegans heat-sensitive mortal germline phenotype.

ABSTRACT: Caenorhabditis elegans strains with the heat-sensitive mortal germline phenotype become progressively sterile over the course of a few tens of generations when maintained at temperatures near the upper range of C. elegans' tolerance. Mortal germline is transgenerationally heritable, and proximately under epigenetic control. Previous studies have suggested that mortal germline presents a relatively large mutational target and that mortal germline is not uncommon in natural populations of C. elegans. The mortal germline phenotype is not monolithic. Some strains exhibit a strong mortal germline phenotype, in which individuals invariably become sterile over a few generations, whereas other strains show a weaker (less penetrant) phenotype in which the onset of sterility is slower and more stoch

SUBMITTER: Saber S 

PROVIDER: S-EPMC9073675 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature