The genome organization of Neurospora crassa at high resolution uncovers principles of fungal chromosome topology.

ABSTRACT: The eukaryotic genome must be precisely organized for its proper function, as genome topology impacts transcriptional regulation, cell division, replication, and repair, among other essential processes. Disruptions to human genome topology can lead to diseases, including cancer. The advent of chromosome conformation capture with high-throughput sequencing (Hi-C) to assess genome organization has revolutionized the study of nuclear genome topology; Hi-C has elucidated numerous genomic structures, including chromosomal territories, active/silent chromatin compartments, Topologically Associated Domains, and chromatin loops. While low-resolution heatmaps can provide important insights into chromosomal level contacts, high-resolution Hi-C datasets are required to reveal folding principles of in

SUBMITTER: Rodriguez S 

PROVIDER: S-EPMC9073679 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature