The E23K Polymorphism of KCNJ11 and Diabetic Retinopathy in Northern Iran.

ABSTRACT: Background: Diabetic Retinopathy (DR) is one of the most severe micro-vascular complications of diabetes mellitus (DM), involving interactions between environmental and genetic risk factors. KCNJ11 gene has a key role in insulin secretion and is of substantial interest in various populations. Methods: A population-based association of 524 T2DM patients was performed to delineate the genetic influence of KCNJ11 polymorphisms (rs5219, c.67A>G or E23K) on the risk of DR in an Iranian population. Genotyping was performed using TaqMan assay. Univariate and MLR analysis controlling for confounders was conducted to evaluate the association between rs5219 and DR. Results: No significant difference was observed in either genotypes distribution (p = 0.83) or allele freque

SUBMITTER: Alidoust L 

PROVIDER: S-EPMC9073720 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature