MiR-99 family is potential target to reverse cerium dioxide nanoparticle-induced placental cell dysfunction.

ABSTRACT:

Background

Cerium dioxide nanoparticles (CeO₂ NPs) are increasingly used as diesel additive, causing a lot of concern about their toxic effects when released into the atmosphere. To date, there is little knowledge about the toxic effects of CeO₂ NPs on the female reproductive system.

Methods

The morphology and size distribution of CeO₂ NPs was observed by transmission electronic microscope (TEM) and Zetasizer Nano, respectively. The uptake of CeO₂ NPs by cells was also observed by TEM after treatment. The cytotoxicity of CeO₂ NPs was studied by Cell Counting Kit-8 (CCK-8), the cellular invasive and migratory ability was examined by transwell assay, the cell apoptosis and reactive oxygen species (ROS) were studied by flow

SUBMITTER: Yao M 

PROVIDER: S-EPMC9073772 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature