Circulating microRNAs in seminal plasma as predictors of sperm retrieval in microdissection testicular sperm extraction.

ABSTRACT:

Background

Because of focal spermatogenesis in some nonobstructive azoospermia (NOA) patients, testicular spermatozoa can be retrieved by microdissection testicular sperm extraction (micro-TESE) for intracytoplasmic sperm injection (ICSI) to achieve successful fertilization. Currently, testicular biopsy is widely performed for the prognosis of micro-TESE; however, it might miss foci with active spermatogenesis because of the 'blind manner' of puncture, highlighting the needs for biomarkers that could indicate actual spermatogenesis conditions in the testis. Thus, we screened microRNAs in the seminal plasma for potential biomarkers to provide a non-invasive and reliable preoperative assessment for micro-TESE.

Methods

We screened the seminal plasma microRNAs from NOA patients

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9073789 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature