Divinylpyrimidine reagents generate antibody-drug conjugates with excellent in vivo efficacy and tolerability.
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ABSTRACT:
SUBMITTER: Walsh SJ
PROVIDER: S-EPMC9073851 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Publications
Divinylpyrimidine reagents generate antibody-drug conjugates with excellent <i>in vivo</i> efficacy and tolerability.
Walsh Stephen J SJ Omarjee Soleilmane S Dannheim Friederike M FM Couturier Dominique-Laurent DL Bexheti Dorentina D Mendil Lee L Cronshaw Gemma G Fewster Toby T Gregg Charlotte C Brodie Cara C Miller Jodi L JL Houghton Richard R Carroll Jason S JS Spring David R DR
Chemical communications (Cambridge, England) 20220208 12
The development of divinylpyrimidine (DVP) reagents for the synthesis of antibody-drug conjugates (ADCs) with <i>in vivo</i> efficacy and tolerability is reported. Detailed structural characterisation of the synthesised ADCs was first conducted followed by <i>in vitro</i> and <i>in vivo</i> evaluation of the ADCs' ability to safely and selectively eradicate target-positive tumours. ...[more]
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