Formation of Salts and Molecular Ionic Cocrystals of Fluoroquinolones and α,ω-Dicarboxylic Acids.

ABSTRACT: The cocrystallization of the fluoroquinolones ciprofloxacin (cip), norfloxacin (nor), and enrofloxacin (enro) with the α,ω-dicarboxylic acids glutaric acid (glu), adipic acid (adi), pimelic acid (pim), suberic acid (sub), azeliac acid (az), and sebacic acid (seb) resulted in 27 new molecular salts and ternary molecular ionic cocrystals of compositions A⁺B^-, A₂ ⁺B^2-, A₂ ⁺B^2-B, and A⁺B^-A. Depending on the solvent, different stoichiomorphs, solvates, or polymorphs were obtained. All salts and cocrystals contain the robust R₂NH₂ ^+...-OOC or R₃NH^+...-OOC synthon but have different supramolecular ring motifs. Moderate solubility enha

SUBMITTER: O'Malley C 

PROVIDER: S-EPMC9073931 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature