Clinical outcomes of COVID-19 infection among patients with Alzheimer's disease or mild cognitive impairment.

ABSTRACT:

Introduction

Alzheimer's disease (AD) and COVID-19 share common risk factors including hypertension. Angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) are frequently prescribed antihypertension medications.

Methods

This study analyzed 436,823 veterans tested for SARS-CoV-2 infection. We conducted both classical and propensity score weighted logistic models to compare COVID-19 outcomes between patients with AD or mild cognitive impairment (MCI) to those without cognitive impairment, and examined effect of ACEI/ARB prescription.

Results

There was a statistically significant association between AD and increased odds of infection and mortality. MCI was not found to be a risk factor for infection. Subjects with MCI exhibited poor cl

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9073985 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature