Impact of autologous stem cell transplantation on long term renal function and associated progression-free and overall survival in multiple myeloma.

ABSTRACT: The long-term impact of Autologous hematopietic stem cell transplantation (ASCT) on renal function, and the impact of renal function on progression-free survival (PFS) and overall survival (OS) in patients with multiple myeloma are not known. We retrospectively reviewed the records of 885 patients at our institution. We used linear mixed effect models to study the change in estimated glomerular filtration rate (eGFR) and a joint model approach to assess associations between the eGFR, PFS and OS. Sensitivity analyses were conducted at days 0, 100, 180, and 365 post-SCT. eGFR post-ASCT was significantly lower than at day 0 but stabilized at approximately 80 mL/min/1.73 m². There was no association between eGFR and PFS or OS.; However, relapsed disease and ISS stage were associated

SUBMITTER: Abudayyeh A 

PROVIDER: S-EPMC9074107 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature