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Metal-free oxidative trifluoromethylation of indoles with CF₃SO₂Na on the C2 position.

ABSTRACT: An efficient method of synthesizing 2-trifluoromethylindoles from indoles with easy-to-handle, cheap and low-toxic CF₃SO₂Na under metal-free conditions is described, which selectively introduces trifluoromethyl to indoles on the C2 position. The desired product can be obtained in 0.7 g yield. A radical intermediate may be involved in this transformation.

SUBMITTER: Xie JJ

PROVIDER: S-EPMC9074110 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Metal-free oxidative trifluoromethylation of indoles with CF3SO2Na on the C2 position.

Xie Jiao-Jiao JJ Wang Zhi-Qing ZQ Jiang Guo-Fang GF

RSC advances 20191030 60

An efficient method of synthesizing 2-trifluoromethylindoles from indoles with easy-to-handle, cheap and low-toxic CF3SO2Na under metal-free conditions is described, which selectively introduces trifluoromethyl to indoles on the C2 position. The desired product can be obtained in 0.7 g yield. A radical intermediate may be involved in this transformation. ...[more]

PMID: 35530675

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