Calcitriol supplementation accelerates the recovery of patients with tuberculosis who have vitamin D deficiency: a randomized, single-blind, controlled clinical trial.

ABSTRACT:

Background

This study aimed to evaluate whether calcitriol supplementation enhances CD4⁺ T cell count and prognosis in patients with tuberculosis and low 25(OH)D levels.

Methods

This randomized controlled clinical trial enrolled treatment-naïve patients with tuberculosis admitted to Zigong First People's Hospital (June 2016 to April 2017). The patients were grouped as the serum 25(OH)D ≥ 75 nmol/L (Normal-25(OH)D) and 25(OH)D < 75 nmol/L (Low-25(OH)D) groups. The Low-Vit-D group was randomized to the Low-25(OH)D and Low-25(OH)D-Calcitriol groups. All patients were treated with the 2HRZE/4HR regimen. The patients in the Low-25(OH)D-Calcitriol group received calcitriol 0.25 µg bid. The main endpoints were CD4⁺ T cell count during treatment, time to sputum

SUBMITTER: Wen Y 

PROVIDER: S-EPMC9074353 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature