Multimetric structural covariance in first-episode major depressive disorder: a graph theoretical analysis.

ABSTRACT:

Background

Abnormalities of cortical morphology have been consistently reported in major depressive disorder (MDD), with widespread focal alterations in cortical thickness, surface area and gyrification. However, it is unclear whether these distributed focal changes disrupt the system-level architecture (topology) of brain morphology in MDD. If present, such a topological disruption might explain the mechanisms that underlie altered cortical morphology in MDD.

Methods

Seventy-six patients with first-episode MDD (33 male, 43 female) and 66 healthy controls (32 male, 34 female) underwent structural MRI scans. We calculated cortical indices, including cortical thickness, surface area and local gyrification index, using FreeSurfer. We constructed morphological covariance network

SUBMITTER: Chen C 

PROVIDER: S-EPMC9074807 | biostudies-literature | 2022 May-Jun

REPOSITORIES: biostudies-literature