The protective effect of propofol on ionizing radiation-induced hematopoietic system damage in mice.

ABSTRACT: The hematopoietic system is highly sensitive to ionizing radiation (IR), and IR can cause injury to hematopoietic stem cells (HSCs); the main reason for this may be elevated reactive oxygen species (ROS) levels. Propofol is an anesthetic drug commonly used in clinical practice. The chemical structure of propofol is similar to that of vitamin E, and propofol has an antioxidant capacity. Therefore, in this work the effect of using propofol to protect against IR-induced hematopoietic system injury is evaluated. The data suggested that when the irradiated mice were treated with 20 mg kg^-1 of propofol, the survival rate of lethally irradiated mice increased significantly, furthermore, the radiation-induced decrease of white blood cells (WBCs), red blood cells (RBCs), hemoglobin (HGC)

SUBMITTER: Han X 

PROVIDER: S-EPMC9075036 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature