Histamine H₂ Receptor Antagonists and Heart Failure Risk in Postmenopausal Women: The Women's Health Initiative.

ABSTRACT: Background Prior studies suggested lower risk of heart failure (HF) in individuals taking H₂ receptor antagonists (H2RA) compared with H2RA nonusers in relatively small studies. We evaluated the association of H2RA use and incident HF in postmenopausal women in the large-scale WHI (Women's Health Initiative) study. Methods and Results This study included postmenopausal women from the WHI without a history of HF at baseline. HF was defined as first incident hospitalization for HF and physician adjudicated. Multivariable Cox proportional hazards regression models evaluated the association of H2RA use as a time-varying exposure with HF risk, after adjustment for demographic, lifestyle, and medical history variables. Sensitivity analyses examined (1) risk of HF stratified by the ARI

SUBMITTER: Larson SR 

PROVIDER: S-EPMC9075064 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature