Social Isolation and Incident Heart Failure Hospitalization in Older Women: Women's Health Initiative Study Findings.

ABSTRACT: Background The association of social isolation or lack of social network ties in older adults is unknown. This knowledge gap is important since the risk of heart failure (HF) and social isolation increase with age. The study examines whether social isolation is associated with incident HF in older women, and examines depressive symptoms as a potential mediator and age and race and ethnicity as effect modifiers. Methods and Results This study included 44 174 postmenopausal women of diverse race and ethnicity from the WHI (Women's Health Initiative) study who underwent annual assessment for HF adjudication from baseline enrollment (1993-1998) through 2018. We conducted a mediation analysis to examine depressive symptoms as a potential mediator and further examined effect modification by age

SUBMITTER: Cene CW 

PROVIDER: S-EPMC9075097 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature