Unknown

Dataset Information

0

Unusual constituents from the medicinal mushroom Ganoderma lingzhi.


ABSTRACT: Extensive studies have revealed that triterpenoids, meroterpenoids, and polysaccharides are the main constituents of the well-known traditional Chinese medicinal mushroom Ganoderma. In this study, we report seven previously undescribed sesquiterpenoids, including six gymnomitranes (1-6) and a novel type of sesquiterpenoid (8), together with a polyketide (7) and a known steroid (9) from the fruiting bodies of Ganoderma lingzhi, a fungus used as traditional medicine and food supplement in East Asia for ages. The structures of 1-8 were deduced by analysis of spectroscopic data, X-ray single crystal diffractions and TDDFT/ECD calculations. Compound 8 possessed an unusual 14(7→6)-cuparane scaffold. Compound 9 exhibited weak cytotoxicity against the five human cancer cell lines HL-60, MCF-7, SW480, A549, and SMMC-7721 with IC50 values of 18.0-32.3 μM. A simple structure-activity-relationship (SAR) investigation by acetylating the 5-OH of 9 (9a) suggested that the 5-OH is essential for its cytotoxicity. Additionally, the biosynthetic pathways for compounds 2 and 8 are discussed.

SUBMITTER: Zhao ZZ 

PROVIDER: S-EPMC9075120 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Unusual constituents from the medicinal mushroom <i>Ganoderma lingzhi</i>.

Zhao Zhen-Zhu ZZ   Liang Xu-Bo XB   Feng Wei-Sheng WS   Wu Ya Y   Zhi Yan-Le YL   Xue Gui-Min GM   Chen He-Ping HP   Liu Ji-Kai JK  

RSC advances 20191113 63


Extensive studies have revealed that triterpenoids, meroterpenoids, and polysaccharides are the main constituents of the well-known traditional Chinese medicinal mushroom <i>Ganoderma</i>. In this study, we report seven previously undescribed sesquiterpenoids, including six gymnomitranes (1-6) and a novel type of sesquiterpenoid (8), together with a polyketide (7) and a known steroid (9) from the fruiting bodies of <i>Ganoderma lingzhi</i>, a fungus used as traditional medicine and food suppleme  ...[more]

Similar Datasets

| S-EPMC6825212 | biostudies-literature
| S-EPMC8466132 | biostudies-literature
| S-EPMC3753355 | biostudies-literature
| S-EPMC3621433 | biostudies-literature
| PRJNA850066 | ENA
| PRJNA995380 | ENA
| S-EPMC9784716 | biostudies-literature
| S-EPMC3982681 | biostudies-literature
| S-EPMC8936451 | biostudies-literature
| S-EPMC9810662 | biostudies-literature