Cu_2-x Se nanoparticles (Cu_2-x Se NPs) mediated neurotoxicity via oxidative stress damage in PC-12 cells and BALB/c mice.

ABSTRACT: Cu_2-x Se nanoparticles (Cu_2-x Se NPs) are widely used for optical diagnostic imaging and photothermal therapy due to their strong near-infrared (NIR) optical absorption. With the continuous expansion of applications using Cu_2-x Se NPs, their biosafety has received increasing attention in recent years. Cu_2-x Se NPs can enter the brain by crossing the blood-brain barrier, but the neurotoxicity of NPs remains unclear. The present investigation provides direct evidence that the toxicity of Cu_2-x Se NPs can be specifically exploited to kill rat pheochromocytoma PC-12 cells (a cell line used as an in vitro model for brain neuron research) in dose- and time-dependent manners. These cytotoxicity events

SUBMITTER: Leng F 

PROVIDER: S-EPMC9075139 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature