Enhanced osteogenesis of mesenchymal stem cells on electrospun cellulose nanocrystals/poly(ε-caprolactone) nanofibers on graphene oxide substrates.

ABSTRACT: Cellulose nanocrystals (CNCs) have received a great amount of attention to the production of micro/nano-platforms for tissue engineering applications. CNCs were extracted from rice husk biomass and characterized by different spectroscopic techniques. The biocompatibility of the extracted CNCs was revealed by the WST-1 assay technique in the presence of human mesenchymal stem cells (hMSCs) after different time intervals. An improvement in the mechanical properties was observed in the fabricated scaffolds (PCL/CNC) compared to PCL scaffolds. Graphene oxide (GO)-coated (PCL/CNC) electrospun scaffolds (GPC) were prepared by the deposition of PCL/CNC composite nanofibers on the surface of GO for tissue engineering. Notably, better cell proliferation and differentiation were observed in the pres

SUBMITTER: Patel DK 

PROVIDER: S-EPMC9075163 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature