Mechanisms of GABAergic and cholinergic neurotransmission in auditory thalamus: Impact of aging.

ABSTRACT: Age-related hearing loss is a complex disorder affecting a majority of the elderly population. As people age, speech understanding becomes a challenge especially in complex acoustic settings and negatively impacts the ability to accurately analyze the auditory scene. This is in part due to an inability to focus auditory attention on a particular stimulus source while simultaneously filtering out other sound stimuli. The present review examines the impact of aging on two neurotransmitter systems involved in accurate temporal processing and auditory gating in auditory thalamus (medial geniculate body; MGB), a critical brain region involved in the coding and filtering of auditory information. The inhibitory neurotransmitter GABA and its synaptic receptors (GABA_ARs) are key to maint

SUBMITTER: Richardson BD 

PROVIDER: S-EPMC9075165 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature