Light-Triggered Drug Release from Red Blood Cells Suppresses Arthritic Inflammation.

ABSTRACT: Arthritis is a leading cause of disability in adults, which can be intensely incapacitating. The location and intensity of the pain is both subjective and challenging to manage. Consequently, patient-directed delivery of anti-inflammatories is an essential component of future therapeutic strategies for the management of this disorder. We describe the design and application of a light responsive red blood cell (RBC) conveyed dexamethasone (Dex) construct that enables targeted drug delivery upon illumination of the inflamed site. The red wavelength (650 nm) responsive nature of the phototherapeutic was validated using tissue phantoms mimicking the light absorbing properties of various skin types. Furthermore, photoreleased Dex has the same impact on cellular responses as conventional Dex. Mu

SUBMITTER: Zywot EM 

PROVIDER: S-EPMC9075171 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature