Macrophage Polarization in the Perivascular Fat Was Associated With Coronary Atherosclerosis.

ABSTRACT: Background Inflammation of the perivascular adipose tissue (PvAT) may be related to atherosclerosis; however, the association of polarized macrophages in the pericoronary PvAT with measurements of atherosclerosis components in humans has not been fully investigated. Methods and Results Coronary arteries were dissected with surrounding PvAT. We evaluated the percentage of arterial obstruction, intima-media thickness, fibrous cap thickness, plaque components, and the number of vasa vasorum. The number of proinflammatory (M1) and anti-inflammatory (M2) macrophages in the periplaque and control PvAT were evaluated using immunohistochemistry. Regression models adjusted for sociodemographic and clinical variables were used. In 319 segments from 82 individuals, we found a correlation of the M1/M2

SUBMITTER: Farias-Itao DS 

PROVIDER: S-EPMC9075275 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature