Epidemiology of Acute Lower Respiratory Tract Infection in HIV-Exposed Uninfected Infants.

ABSTRACT:

Background

Increased morbidity and mortality from lower respiratory tract infection (LRTI) has been suggested in HIV-exposed uninfected (HEU) children; however, the contribution of respiratory viruses is unclear. We studied the epidemiology of LRTI hospitalization in HIV-unexposed uninfected (HUU) and HEU infants aged <6 months in South Africa.

Methods

We prospectively enrolled hospitalized infants with LRTI from 4 provinces from 2010 to 2013. Using polymerase chain reaction, nasopharyngeal aspirates were tested for 10 viruses and blood for pneumococcal DNA. Incidence for 2010-2011 was estimated at 1 site with population denominators.

Results

We enrolled 3537 children aged <6 months. HIV infection and exposure status were determined for 2507 (71%), of whom 211 (8%) we

SUBMITTER: Cohen C 

PROVIDER: S-EPMC9075335 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature