Migraine-Associated Mutation in the Na,K-ATPase Leads to Disturbances in Cardiac Metabolism and Reduced Cardiac Function.

ABSTRACT: Background Mutations in ATP1A2 gene encoding the Na,K-ATPase α₂ isoform are associated with familial hemiplegic migraine type 2. Migraine with aura is a known risk factor for heart disease. The Na,K-ATPase is important for cardiac function, but its role for heart disease remains unknown. We hypothesized that ATP1A2 is a susceptibility gene for heart disease and aimed to assess the underlying disease mechanism. Methods and Results Mice heterozygous for the familial hemiplegic migraine type 2-associated G301R mutation in the Atp1a2 gene (α₂^+/G301R mice) and matching wild-type controls were compared. Reduced expression of the Na,K-ATPase α₂ isoform and increased expression of the α₁ isoform were observed in hearts fro

SUBMITTER: Staehr C 

PROVIDER: S-EPMC9075430 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature