Platelet-Derived Growth Factor Receptor Type α Activation Drives Pulmonary Vascular Remodeling Via Progenitor Cell Proliferation and Induces Pulmonary Hypertension.

ABSTRACT: Background Platelet-derived growth factor is a major regulator of the vascular remodeling associated with pulmonary arterial hypertension. We previously showed that protein widely 1 (PW1⁺) vascular progenitor cells participate in early vessel neomuscularization during experimental pulmonary hypertension (PH) and we addressed the role of the platelet-derived growth factor receptor type α (PDGFRα) pathway in progenitor cell-dependent vascular remodeling and in PH development. Methods and Results Remodeled pulmonary arteries from patients with idiopathic pulmonary arterial hypertension showed an increased number of perivascular and vascular PW1⁺ cells expressing PDGFRα. PW1^nLacZ reporter mice were used to follow the fate of pulmonary PW1⁺ progenitor

SUBMITTER: Solinc J 

PROVIDER: S-EPMC9075467 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature