Soluble ST2 Is a Sensitive and Specific Biomarker for Fulminant Myocarditis.

ABSTRACT: Background The aim of the study was to identify biomarkers that can facilitate early diagnosis and treatment of fulminant myocarditis (FM) in order to reduce mortality. Methods and Results First, the expression profiles of circulating cytokines were determined in the plasma samples from 4 patients with FM and 4 controls using human cytokine arrays. The results showed that 39 cytokines from patients with FM were changed at admission. Among them, 8 cytokines returned to normal levels at discharge, including soluble ST2 (sST2), which showed the most marked dynamic changes from disease onset to resolution. Then, in a cohort of 76 patients with FM, 57 patients with acute hemodynamic dysfunction attributable to other causes, and 56 patients with non-FM, receiver operating characteristic curve an

SUBMITTER: Wang J 

PROVIDER: S-EPMC9075487 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature