Deoxycholic Acid and Coronary Artery Calcification in the Chronic Renal Insufficiency Cohort.

ABSTRACT: Background Deoxycholic acid (DCA) is a secondary bile acid that may promote vascular calcification in experimental settings. Higher DCA levels were associated with prevalent coronary artery calcification (CAC) in a small group of individuals with advanced chronic kidney disease. Whether DCA levels are associated with CAC prevalence, incidence, and progression in a large and diverse population of individuals with chronic kidney disease stages 2 to 4 is unknown. Methods and Results In the CRIC (Chronic Renal Insufficiency Cohort) study, we evaluated cross-sectional (n=1057) and longitudinal (n=672) associations between fasting serum DCA levels and computed tomographic CAC using multivariable-adjusted regression models. The mean age was 57±12 years, 47% were women, and 41% were Black. At base

SUBMITTER: Jovanovich A 

PROVIDER: S-EPMC9075491 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature