The effects of trace metal impurities on Ga-68-radiolabelling with a tris(3-hydroxy-1,6-dimethylpyridin-4-one) (THP) chelator.

ABSTRACT: GMP-grade ⁶⁸Ge/⁶⁸Ga generators provide access to positron-emitting ⁶⁸Ga, enabling preparation of Positron Emission Tomography (PET) tracers and PET imaging at sites that do not have access to cyclotron-produced radionuclides. Radiotracers based on tris(3-hydroxy-1,6-dimethylpyridin-4-one) (THP) chelators enable simple one-step preparations of ⁶⁸Ga PET radiopharmaceuticals from pre-fabricated kits without pre-processing of generator eluate or post-purification. However, trace metal impurities eluted along with ⁶⁸Ga could compete for THP and reduce radiochemical yields (RCY). We have quantified trace metal impurities in ⁶⁸Ga eluate from an Eckert & Ziegler (E&Z) generator using ICP-MS. The metals Al, Fe, ^natGa, Pb,

SUBMITTER: Cusnir R 

PROVIDER: S-EPMC9075519 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature