Remote loading of curcumin-in-modified β-cyclodextrins into liposomes using a transmembrane pH gradient.

ABSTRACT: Curcumin (CRM) is a natural polyphenol with antioxidative, anti-inflammatory, and anticancer therapeutic properties. However, CRM therapeutic potential is limited by low water solubility and bioavailability. Intraliposomal remote loading describes the retention of drugs in liposome cores in response to transmembrane pH gradient. The current study describes for the first time the remote loading of CRM into liposomes using secondary (E-βCD) and tertiary (D-βCD) amino-modified β-cyclodextrins (βCDs) as carriers and solubilizers. βCDs were chemically modified to prepare the ionizable weak base functional group followed by forming a guest-host complex of CRM in the modified βCDs hydrophobic cavities via a solvent evaporation encapsulation technique. These complexes were then actively loa

SUBMITTER: Odeh F 

PROVIDER: S-EPMC9075600 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature