Innate immune cell response to host-parasite interaction in a human intestinal tissue microphysiological system.

ABSTRACT: Protozoan parasites that infect humans are widespread and lead to varied clinical manifestations, including life-threatening illnesses in immunocompromised individuals. Animal models have provided insight into innate immunity against parasitic infections; however, species-specific differences and complexity of innate immune responses make translation to humans challenging. Thus, there is a need for in vitro systems that can elucidate mechanisms of immune control and parasite dissemination. We have developed a human microphysiological system of intestinal tissue to evaluate parasite-immune-specific interactions during infection, which integrates primary intestinal epithelial cells and immune cells to investigate the role of innate immune cells during epithelial infection by the protozoan pa

SUBMITTER: Humayun M 

PROVIDER: S-EPMC9075809 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature